Clinical Manifestations

Patients with MF have significant disease burden, with debilitating symptoms that are progressive, relentless, and detrimental to QOL.3,11



Splenomegaly, present in approximately 85% of patients with MF, occurs because the inability of the bone marrow to produce normal blood cells forces the spleen to do so.2,12

 
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Splenomegaly > 8 cm below the left costal margin and progressive anemia are common in patients with MF. Some patients may require blood transfusions.13-15



MPN-related symptoms are driven by the increased production of circulating inflammatory cytokines resulting from the abnormal activation of JAK signaling.5



Splenomegaly, cytopenias, and MPN-related symptoms generally worsen over the course of the disease.3,14-16

 
 
 

References

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