What is Myelofibrosis?
Myelofibrosis (MF) is caused by an abnormality in the cells that make platelets. It results in bone marrow being replaced by scar (fibrous) tissue.
Myelofibrosis is a disorder of the bone marrow. It occurs when the marrow – the soft, fatty tissue inside your bones that produces stem cells – is replaced by fibrous (or scar) tissue. Scarring of the bone marrow means the marrow is not able to make enough blood cells. The liver and spleen try to compensate by producing their own blood cells, but this can cause them to swell. MF can also lead to anemia and bleeding problems, as well as a higher risk of infections.
Learn more about the role of bone marrow and stem cells
THE ROLE OF BONE MARROW AND STEM CELLS
A cross section of bone (marrow)
Bone marrow is the soft, spongy tissue that fills the inner cavities of the bone. It's where red blood cells, white blood cells and platelets are formed. It also contains fluid, blood vessels and fat.
The bone marrow is either red or yellow. When we are born, we only have red marrow, which is responsible for creating new blood cells. As we get older, some of the red marrow is replaced by yellow marrow, which is largely fat. A healthy adult has both red and yellow marrow.